CBG (Cannabigerol) is a non-intoxicating cannabinoid found in the Cannabis of plants. CBG is the non-acidic form of cannabigerolic acid (CBGA), the parent molecule from which many other cannabinoids are made. As with all cannabinoids, CBG is a hydrophobic lipid consisting of a 21-carbon chain linked to an aromatic hydrocarbon ring.
It is a precursor to the three main branches of cannabinoids: tetrahydrocannabinol acid (THCA), cannabidiol acid (CBDA) and cannabenzoic acid (CBCA).CBG is not psychoactive, affects the 5HT1 receptor, which supports the regulation of the release of serotonin and areno receptor, which controls the expression of adrenaline and noradrenaline in the entire central nervous system.
“In this study, we investigated 18 commercially available cannabinoids and they all showed antibiotic activity, some much more than others,” said study lead Eric Brown, professor of biochemistry and biomedical sciences at McMaster.
“The one we focused on was a non-psychoactive cannabinoid called CBG, as it had the most promising activity. We synthesized that cannabinoid in mass quantity which gave us sufficient compound to go deep into the research.”
The research team found that CBG had antibacterial activity against drug-resistant MRSA. It prevented the ability of that bacteria to form biofilms, which are communities of microorganisms that attach to each other and to surfaces; and it destroyed preformed biofilms and cells resistant to antibiotics. CBG achieved this by targeting the cell membrane of the bacteria.
These findings in the laboratory were supported when mice with an MRSA infection were given CBG.
“CBG proved to be marvellous at tackling pathogenic bacteria,” Brown said. “The findings suggest real therapeutic potential for cannabinoids as antibiotics.”